* Generic Name: phenytoin
* Brand Name: Dilantin
* What is phenytoin?
* What are the possible side effects of phenytoin?
* What is the most important information I should know about
phenytoin?
* What should I discuss with my healthcare provider before taking
phenytoin?
* How should I take phenytoin?
* What happens if I miss a dose?
* What happens if I overdose?
* What should I avoid while taking phenytoin?
* What other drugs will affect phenytoin?
* Where can I get more information?
What is phenytoin?
Phenytoin is an anti-epileptic drug, also called an
anticonvulsant. It works by slowing down impulses in the brain that
cause seizures.
Phenytoin is used to control seizures. Phenytoin does not treat all
types of seizures, and your doctor will determine if it is the right
medicine for you.
Phenytoin may also be used for purposes not listed in this medication
guide.
What are the possible side effects of phenytoin?
Get emergency medical help if you have signs of an allergic reaction
(hives, difficult breathing, swelling in your face or throat) or a
severe skin reaction (fever, sore throat, burning in your eyes,
skin pain, red or purple skin rash that spreads and causes blistering
and peeling).
Seek medical treatment if you have a serious drug reaction that can
affect many parts of your body. Symptoms may include: skin rash, fever,
swollen glands, flu-like symptoms, muscle aches, severe weakness,
unusual bruising, or yellowing of your skin or eyes. This reaction may
occur several weeks after you began using phenytoin.
Report any new or worsening symptoms to your doctor, such as: mood or
behavior changes, anxiety, panic attacks, trouble sleeping, or if
you feel impulsive, irritable, agitated, hostile, aggressive, restless,
hyperactive (mentally or physically), more depressed, or have thoughts
about suicide or hurting yourself.
Call your doctor at once if you have:
* sudden weakness or ill feeling, fever, chills, sore throat,
mouth sores;
* skin rash, easy bruising or bleeding, severe weakness;
* severe muscle pain;
* bone pain (especially in your hips, legs, or lower back), trouble
with walking; or
* liver problems--loss of appetite, upper stomach pain, dark
urine, clay-colored stools, jaundice (yellowing of the skin or
eyes).
Common side effects may include:
* dizziness, drowsiness, confusion, nervousness;
* nausea, vomiting, constipation;
* tremors, slurred speech, loss of balance or coordination;
* rash;
* abnormal eye movement;
* headache; or
* sleep problems (insomnia).
This is not a complete list of side effects and others may occur. Call
your doctor for medical advice about side effects. You may report side
effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about phenytoin?
You should not use phenytoin if you also take delavirdine
(Rescriptor).
Dilantin Patient Information including How Should I Take
Epilepsy:Symptoms, Stages and Treatment
Epilepsy Slideshow
RxList
Brain Disorders Image Collection
RxList
Take the Epilepsy (Seizure Disorder) Quiz
What should I discuss with my healthcare provider before taking phenytoin?
You should not use this medicine if you are allergic to phenytoin or
similar medicines such as ethotoin, fosphenytoin, or mephenytoin, or if
you have:
* a history of liver problems caused by phenytoin;
* a heart condition called 2nd or 3rd degree "AV block";
* a history of slow heartbeats that have caused you to faint; or
* a condition for which you also take delavirdine (Rescriptor).
To make sure phenytoin is safe for you, tell your doctor if you have
ever had:
* liver disease;
* an abnormal heart rhythm found on an EKG (electrocardiograph);
* diabetes;
* depression;
* suicidal thoughts or actions;
* a vitamin D deficiency or any other condition that causes
thinning of the bones;
* porphyria (a genetic enzyme disorder that causes symptoms
affecting the skin or nervous system); or
* if you drink large amounts of alcohol.
You may have thoughts about suicide while taking this medicine. Your
doctor will need to check your progress at regular visits while you are
using phenytoin. Your family or other caregivers should also be alert
to changes in your mood or symptoms.
Patients of Asian ancestry may have a higher risk of developing a rare
but serious skin reaction to phenytoin. Your doctor may recommend a
blood test before you start the medication to determine your risk of
this skin reaction.
Seizure control is very important during pregnancy. Do not start or
stop taking this medicine without your doctor's advice if you are
pregnant. Phenytoin may cause harm to an unborn baby, but having a
seizure during pregnancy could harm both mother and baby. Tell your
doctor right away if you become pregnant while taking this medicine.
If you become pregnant while taking phenytoin, your name may be listed
on a pregnancy registry. This is to track the outcome of the pregnancy
and to evaluate any effects of phenytoin on the baby.
Phenytoin can make birth control pills less effective. Ask your doctor
about using non hormonal birth control (condom, diaphragm with
spermicide) to prevent pregnancy while taking phenytoin.
Phenytoin can pass into breast milk and may harm a nursing baby. You
should not breast-feed while you are using phenytoin.
How should I take phenytoin?
Follow all directions on your prescription label. Do not take this
medicine in larger or smaller amounts or for longer than recommended.
Do not crush, chew, break, or open an extended-release capsule. Swallow
it whole. Do not use any phenytoin capsule that has changed colors.
Call your doctor for a new prescription.
The chewable tablet must be chewed before you swallow it.
Shake the oral suspension (liquid) well just before you measure a dose.
Measure liquid medicine with the dosing syringe provided, or with a
special dose-measuring spoon or medicine cup. If you do not have a
dose-measuring device, ask your pharmacist for one.
While using phenytoin, you may need frequent blood tests. You may also
need a blood test when switching from one form of phenytoin to another.
Visit your doctor regularly.
If you are taking phenytoin to treat seizures, do not stop using
phenytoin suddenly, even if you feel fine. Stopping suddenly may cause
increased seizures. Follow your doctor's instructions about tapering
your dose.
Tell your doctor if this medicine does not seem to work as well in
treating your condition.
Wear a medical alert tag or carry an ID card stating that you take
phenytoin. Any medical care provider who treats you should know that
you take seizure medication.
Phenytoin can cause swelling in your gums. Brush and floss your teeth
and visit your dentist regularly to help prevent this problem.
Store at room temperature away from moisture, light, and heat.
Dilantin Patient Information including If I Miss a Dose
Epilepsy:Symptoms, Stages and Treatment
Epilepsy Slideshow
RxList
Brain Disorders Image Collection
RxList
Take the Epilepsy (Seizure Disorder) Quiz
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if
it is almost time for your next scheduled dose. Do not take extra
medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at
1-800-222-1222. An overdose of phenytoin can be fatal. Overdose
symptoms may include twitching eye movements, slurred speech, loss
of balance, tremor, muscle stiffness or weakness, nausea, vomiting,
feeling light-headed, fainting, and slow or shallow breathing.
What should I avoid while taking phenytoin?
Avoid drinking alcohol while you are taking phenytoin. Alcohol use can
increase your blood levels of phenytoin and may increase side effects.
Daily alcohol use can decrease your blood levels of phenytoin, which
can increase your risk of seizures.
Avoid taking antacids at the same time you take phenytoin. Antacids
can make it harder for your body to absorb the medication.
Phenytoin may impair your thinking or reactions. Be careful if you
drive or do anything that requires you to be alert.
What other drugs will affect phenytoin?
Sometimes it is not safe to use certain medications at the same time.
Some drugs can raise or lower your blood levels of phenytoin, which may
cause side effects or make phenytoin less effective. Phenytoin can also
affect blood levels of certain other drugs, making them less effective
or increasing side effects.
Taking phenytoin with other drugs that make you sleepy or slow your
breathing can increase these effects. Ask your doctor before taking
phenytoin with a sleeping pill, narcotic pain medicine, muscle
relaxer, or medicine for anxiety, depression, or seizures.
Many drugs can interact with phenytoin. Not all possible interactions
are listed here. TELL YOUR DOCTOR ABOUT ALL OTHER MEDICINES YOU USE,
and any you start or stop using during treatment with phenytoin. This
includes prescription and over-the-counter medicines, vitamins, and
herbal products.
Where can I get more information?
Your pharmacist can provide more information about phenytoin.
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