* Generic Name: pentoxifylline
* Brand Name: Trental
* What is pentoxifylline (Pentoxil, TRENtal)?
* What are the possible side effects of pentoxifylline (Pentoxil,
TRENtal)?
* What is the most important information I should know about
pentoxifylline (Pentoxil, TRENtal)?
* What should I discuss with my healthcare provider before taking
pentoxifylline (Pentoxil, TRENtal)?
* How should I take pentoxifylline (Pentoxil, TRENtal)?
* What happens if I miss a dose (Pentoxil, TRENtal)?
* What happens if I overdose (Pentoxil, TRENtal)?
* What should I avoid while taking pentoxifylline (Pentoxil,
TRENtal)?
* What other drugs will affect pentoxifylline (Pentoxil,
TRENtal)?
* Where can I get more information (Pentoxil, TRENtal)?
What is pentoxifylline (Pentoxil, TRENtal)?
Pentoxifylline causes changes in your blood that help improve blood
flow. This also helps your blood carry oxygen to your tissues and
organs.
Pentoxifylline is used to improve blood flow and reduce certain
symptoms of a condition called intermittent claudication
(IN-ter-MIT-ent KLOD-ih-KAY-tion). Pentoxifylline is not a cure for
this condition.
Pentoxifylline may also be used for purposes not listed in this
medication guide.
What are the possible side effects of pentoxifylline (Pentoxil, TRENtal)?
Stop taking pentoxifylline and get emergency medical help if you have
any of these signs of an allergic reaction: hives; difficult breathing;
swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
* chest pain;
* pounding heartbeats or fluttering in your chest;
* red or pink urine;
* a light-headed feeling, like you might pass out; or
* signs of stomach bleeding--bloody or tarry stools, coughing up
blood or vomit that looks like coffee grounds.
Common side effects may include:
* dizziness, headache;
* nausea, vomiting;
* diarrhea, gas; or
* bloating, upset stomach.
This is not a complete list of side effects and others may occur. Call
your doctor for medical advice about side effects. You may report side
effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about pentoxifylline
(Pentoxil, TRENtal)?
You should not use this medicine if you have recently had any type of
bleeding in your brain or the retina of your eye.
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What should I discuss with my healthcare provider before taking
pentoxifylline (Pentoxil, TRENtal)?
You should not use this medicine if you are allergic to pentoxifylline,
or if you are allergic to caffeine or theophylline
(Elixophyllin, Theo-24, Theo-Dur, Slo-Bid, Theochron,
Theolair, Uniphyl, and others).
You also should not use pentoxifylline if you have recently had any
type of bleeding in your brain or the retina of your eyes.
To make sure pentoxifylline is safe for you, tell your doctor if you
have:
* coronary artery disease (hardened arteries);
* liver or kidney disease;
* heart disease;
* a history of bleeding in your brain or inside your eyes;
* history of heart attack or stroke;
* a stomach or intestinal ulcer;
* if you have recently had surgery;
* if you are also using theophylline; or
* if you use medicine to treat or prevent blod clots.
It is not known whether pentoxifylline will harm an unborn baby. Tell
your doctor if you are pregnant or plan to become pregnant while using
this medicine.
Pentoxifylline can pass into breast milk and may harm a nursing baby.
You should not breast-feed while you are using pentoxifylline.
How should I take pentoxifylline (Pentoxil, TRENtal)?
Follow all directions on your prescription label. Do not take this
medicine in larger or smaller amounts or for longer than recommended.
Pentoxifylline is usually taken 3 times each day, with meals. Follow
your doctor's instructions.
While using pentoxifylline, you may need frequent blood tests.
Do not crush, chew, or break an extended-release tablet. Swallow it
whole.
It may take up to 4 weeks before your symptoms improve. Keep using the
medicine as directed and tell your doctor if your symptoms do not
improve after 8 weeks of treatment.
Store at room temperature away from moisture, heat, and light.
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What happens if I miss a dose (Pentoxil, TRENtal)?
Take the missed dose as soon as you remember. Skip the missed dose if
it is almost time for your next scheduled dose. Do not take extra
medicine to make up the missed dose.
What happens if I overdose (Pentoxil, TRENtal)?
Seek emergency medical attention or call the Poison Help line at
1-800-222-1222.
Overdose symptoms may include severe drowsiness, agitation, fever,
flushing (warmth, redness, or tingly feeling), fainting, or
seizure.
What should I avoid while taking pentoxifylline (Pentoxil, TRENtal)?
Follow your doctor's instructions about any restrictions on food,
beverages, or activity.
What other drugs will affect pentoxifylline (Pentoxil, TRENtal)?
If you also take a blood thinner such as warfarin (Coumadin,
Jantoven), you may need more frequent "INR" or prothrombin time
tests to measure your blood-clotting time.
Other drugs may interact with pentoxifylline, including prescription
and over-the-counter medicines, vitamins, and herbal products. Tell
each of your health care providers about all medicines you use now and
any medicine you start or stop using.
Where can I get more information (Pentoxil, TRENtal)?
Your pharmacist can provide more information about pentoxifylline.
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