Remeron

Remeron

     * Generic Name: mirtazapine
     * Brand Name: Remeron


     * What is mirtazapine?
     * What are the possible side effects of mirtazapine?
     * What is the most important information I should know about
       mirtazapine?
     * What should I discuss with my healthcare provider before taking
       mirtazapine?
     * How should I take mirtazapine?
     * What happens if I miss a dose?
     * What happens if I overdose?
     * What should I avoid while taking mirtazapine?
     * What other drugs will affect mirtazapine?
     * Where can I get more information?

What is mirtazapine?

   Mirtazapine is an antidepressant. Mirtazapine affects chemicals
   in the brain that may be unbalanced in people with depression.

   Mirtazapine is used to treat major depressive disorder.

   Mirtazapine may also be used for purposes not listed in this medication
   guide.

What are the possible side effects of mirtazapine?

   Get emergency medical help if you have signs of an allergic reaction:
   skin rash or hives; difficult breathing; swelling of your face, lips,
   tongue, or throat.

   Report any new or worsening symptoms to your doctor, such as: mood or
   behavior changes, anxiety, panic attacks, trouble sleeping, or if
   you feel impulsive, irritable, agitated, hostile, aggressive, restless,
   hyperactive (mentally or physically), more depressed, or have thoughts
   about suicide or hurting yourself.

   Call your doctor at once if you have:
     * racing thoughts, decreased need for sleep, unusual risk-taking
       behavior, feelings of extreme happiness or sadness, being more
       talkative than usual;
     * blurred vision, tunnel vision, eye pain or swelling, or
       seeing halos around lights;
     * a light-headed feeling, like you might pass out;
     * changes in weight or appetite;
     * sudden weakness or ill feeling, fever, chills, sore throat,
       mouth sores, red or swollen gums, trouble swallowing;
     * rash, blisters, oozing, or severe pain in the palms of your
       hands or the soles of your feet;
     * high levels of serotonin in the body--agitation,
       hallucinations, fever, fast heart rate, overactive reflexes,
       nausea, vomiting, diarrhea, loss of coordination, fainting;
     * low levels of sodium in the body--headache, confusion, slurred
       speech, severe weakness, vomiting, loss of coordination, feeling
       unsteady; or
     * severe nervous system reaction--very stiff (rigid) muscles, high
       fever, sweating, confusion, fast or uneven heartbeats, tremors,
       feeling like you might pass out.

   Common side effects include:
     * drowsiness, dizziness;
     * strange dreams;
     * vision changes;
     * dry mouth;
     * constipation;
     * increased appetite; or
     * weight gain.

   This is not a complete list of side effects and others may occur. Call
   your doctor for medical advice about side effects. You may report side
   effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about mirtazapine?

   You should not take mirtazepine if you are also taking tryptophan
   (sometimes called L-tryptophan).

   Do not use mirtazepine if you have used an MAO inhibitor in the past 14
   days. A dangerous drug interaction could occur. MAO inhibitors include
   isocarboxazid, linezolid, methylene blue injection, phenelzine,
   rasagiline, selegiline, tranylcypromine, and others.

   Some young people have thoughts about suicide when first taking an
   antidepressant. Your doctor will need to check your progress at regular
   visits while you are using mirtazepine. Your family or other caregivers
   should also be alert to changes in your mood or symptoms.

   Report any new or worsening symptoms to your doctor, such as: mood or
   behavior changes, anxiety, panic attacks, trouble sleeping, or if you
   feel impulsive, irritable, agitated, hostile, aggressive, restless,
   hyperactive (mentally or physically), more depressed, or have thoughts
   about suicide or hurting yourself.

   Do not give this medicine to anyone younger than 18 years old without
   the advice of a doctor. Mirtazepine is not approved for use in
   children.

   Remeron Patient Information including How Should I Take
   Depression Overview:What is Depression?

   Understanding Depression Slideshow
   RxList

   Take the Depression Quiz
   Depression:Tips for Exercise Diet and Stress Reduction

   Depression Tips Slideshow Pictures

What should I discuss with my healthcare provider before taking mirtazapine?

   You should not take this medicine if you are allergic to mirtazapine,
   or if you are also taking tryptophan (sometimes called L-tryptophan).

   Do not use mirtazepine if you have used an MAO inhibitor in the past 14
   days. A dangerous drug interaction could occur. MAO inhibitors include
   isocarboxazid, linezolid, methylene blue injection, phenelzine,
   rasagiline, selegiline, tranylcypromine, and others.

   To make sure mirtazepine is safe for you, tell your doctor if you have:
     * liver or kidney disease;
     * narrow-angle glaucoma;
     * bipolar disorder (manic depression);
     * seizures or epilepsy;
     * low blood pressure or dizzy spells;
     * high cholesterol or triglycerides;
     * heart disease, including angina (chest pain);
     * a history of heart attack or stroke; or
     * a history of drug abuse or suicidal thoughts.

   Some young people have thoughts about suicide when first taking an
   antidepressant. Your doctor will need to check your progress at regular
   visits while you are using mirtazepine. Your family or other caregivers
   should also be alert to changes in your mood or symptoms.

   It is not known whether mirtazapine will harm an unborn baby. Tell your
   doctor if you are pregnant or plan to become pregnant while using this
   medication.

   It is not known whether mirtazepine passes into breast milk or if it
   could harm a nursing baby. Tell your doctor if you are breast-feeding a
   baby.

   The orally disintegrating tablet may contain phenylalanine. Talk to
   your doctor before using this form of mirtazapine if you have
   phenylketonuria (PKU).

How should I take mirtazapine?

   Follow all directions on your prescription label. Do not take this
   medicine in larger or smaller amounts or for longer than recommended.

   Mirtazapine is usually taken once a day at bedtime. Follow your
   doctor's instructions.

   Take the regular tablet form of mirtazapine with water.

   To take the orally disintegrating tablet (Remeron SolTab):
     * Keep the tablet in its blister pack until you are ready to take it.
       Open the package and peel back the foil. Do not push a tablet
       through the foil or you may damage the tablet.
     * Use dry hands to remove the tablet and place it in your mouth.
     * Do not swallow the tablet whole. Allow it to dissolve in your mouth
       without chewing. If desired, you may drink liquid to help swallow
       the dissolved tablet.

   It may take up to several weeks before your symptoms improve. Keep
   using the medication as directed and tell your doctor if your symptoms
   do not improve after 4 weeks of treatment.

   Do not stop using mirtazepine suddenly, or you could have unpleasant
   withdrawal symptoms. Ask your doctor how to safely stop using
   mirtazepine.

   Store at room temperature away from moisture, heat, and light.

   Remeron Patient Information including If I Miss a Dose
   Depression Overview:What is Depression?

   Understanding Depression Slideshow
   RxList

   Take the Depression Quiz
   Depression:Tips for Exercise Diet and Stress Reduction

   Depression Tips Slideshow Pictures

What happens if I miss a dose?

   Take the missed dose as soon as you remember. Skip the missed dose if
   it is almost time for your next scheduled dose. Do not take extra
   medicine to make up the missed dose.

What happens if I overdose?

   Seek emergency medical attention or call the Poison Help line at
   1-800-222-1222.

   Overdose symptoms may include confusion, memory problems, drowsiness,
   and fast heart rate.

What should I avoid while taking mirtazapine?

   Avoid drinking alcohol. It may increase certain side effects of
   mirtazapine.

   Mirtazapine may impair your thinking or reactions. Be careful if you
   drive or do anything that requires you to be alert.

What other drugs will affect mirtazapine?

   Taking this medicine with other drugs that make you sleepy can worsen
   this effect. Ask your doctor before taking mirtazepine with a sleeping
   pill, narcotic pain medicine, muscle relaxer, or medicine for
   anxiety, depression, or seizures.

   Tell your doctor about all medicines you use, and those you start or
   stop using during your treatment with mirtazepine, especially:
     * cimetidine (Tagamet);
     * diazepam (Valium);
     * ketoconazole;
     * St. John's wort;
     * tramadol;
     * tryptophan (sometimes called L-tryptophan);
     * medicine to treat mood disorders, thought disorders, or mental
       illness--such as lithium, other antidepressants, or
       antipsychotics;
     * migraine headache medicine--sumatriptan, zolmitriptan,
       and others; or
     * seizure medicine--carbamazepine, phenytoin.

   Other drugs may interact with mirtazepine, including prescription and
   over-the-counter medicines, vitamins, and herbal products. Tell each of
   your health care providers about all medicines you use now and any
   medicine you start or stop using.

Where can I get more information?

   Your pharmacist can provide more information about mirtazapine.
     __________________________________________________________________


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