* Generic Name: indomethacin
* Brand Name: Indocin
* What is indomethacin (Indocin, Indocin SR, Tivorbex)?
* What are the possible side effects of indomethacin (Indocin,
Indocin SR, Tivorbex)?
* What is the most important information I should know about
indomethacin (Indocin, Indocin SR, Tivorbex)?
* What should I discuss with my healthcare provider before taking
indomethacin (Indocin, Indocin SR, Tivorbex)?
* How should I take indomethacin (Indocin, Indocin SR, Tivorbex)?
* What happens if I miss a dose (Indocin, Indocin SR, Tivorbex)?
* What happens if I overdose (Indocin, Indocin SR, Tivorbex)?
* What should I avoid while taking indomethacin (Indocin, Indocin
SR, Tivorbex)?
* What other drugs will affect indomethacin (Indocin, Indocin SR,
Tivorbex)?
* Where can I get more information (Indocin, Indocin SR,
Tivorbex)?
What is indomethacin (Indocin, Indocin SR, Tivorbex)?
Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID).
Indomethacin works by reducing hormones that cause inflammation and
pain in the body.
Indomethacin is used to treat moderate to severe osteoarthritis,
rheumatoid arthritis, gouty arthritis, or ankylosing
spondylitis. Indomethacin is also used to treat shoulder pain
caused by bursitis or tendinitis.
Extended-release indomethacin (Indocin SR) should not be used to treat
gouty arthritis.
Indomethacin may also be used for purposes not listed in this
medication guide.
What are the possible side effects of indomethacin (Indocin, Indocin SR,
Tivorbex)?
Get emergency medical help if you have signs of an allergic reaction:
sneezing, runny or stuffy nose; wheezing or trouble
breathing; hives; swelling of your face, lips, tongue, or throat.
Get emergency medical help if you have signs of a heart attack or
stroke: chest pain spreading to your jaw or shoulder, sudden
numbness or weakness on one side of the body, slurred speech,
feeling short of breath.
Stop using indomethacin and call your doctor at once if you have:
* changes in your vision;
* shortness of breath (even with mild exertion);
* swelling or rapid weight gain;
* the first sign of any skin rash, no matter how mild;
* signs of stomach bleeding--bloody or tarry stools, coughing up
blood or vomit that looks like coffee grounds;
* liver problems--nausea, upper stomach pain, itching, tired feeling,
flu-like symptoms, loss of appetite, dark urine,
clay-colored stools, jaundice (yellowing of the skin or eyes);
* kidney problems--little or no urinating, painful or difficult
urination, swelling in your feet or ankles, feeling tired or short
of breath;
* low red blood cells (anemia)--pale skin, feeling light-headed
or short of breath, rapid heart rate, trouble concentrating; or
* severe skin reaction--fever, sore throat, swelling in your face
or tongue, burning in your eyes, skin pain followed by a red or
purple skin rash that spreads (especially in the face or upper
body) and causes blistering and peeling.
Common side effects may include:
* upset stomach, nausea, vomiting;
* diarrhea, constipation;
* headache, dizziness, drowsiness;
* feeling tired or depressed; or
* ringing in your ears.
This is not a complete list of side effects and others may occur. Call
your doctor for medical advice about side effects. You may report side
effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about indomethacin
(Indocin, Indocin SR, Tivorbex)?
Indomethacin can increase your risk of fatal heart attack or stroke,
especially if you use it long term or take high doses, or if you have
heart disease. Do not use this medicine just before or after heart
bypass surgery (coronary artery bypass graft, or CABG).
Indomethacin may also cause stomach or intestinal bleeding, which can
be fatal. These conditions can occur without warning while you are
using indomethacin, especially in older adults.
Indocin Patient Information including How Should I Take
Rheumatoid Arthritis Symptoms and Treatment
Rheumatoid Arthritis Slideshow
RxList
Take the RA Quiz
Rheumatoid Arthritis Exercises:Joint-Friendly Fitness Routines
Joint-Friendly Exercises Slideshow
What should I discuss with my healthcare provider before taking indomethacin
(Indocin, Indocin SR, Tivorbex)?
Indomethacin can increase your risk of fatal heart attack or stroke,
especially if you use it long term or take high doses, or if you have
heart disease. Even people without heart disease or risk factors could
have a stroke or heart attack while taking this medicine.
Do not use this medicine just before or after heart bypass surgery
(coronary artery bypass graft, or CABG).
Indomethacin may also cause stomach or intestinal bleeding, which can
be fatal. These conditions can occur without warning while you are
using indomethacin, especially in older adults.
You should not use indomethacin if you are allergic to it, or if you
have ever had an asthma attack or severe allergic reaction after
taking aspirin or an NSAID.
To make sure indomethacin is safe for you, tell your doctor if you
have:
* heart disease, high blood pressure, high cholesterol,
diabetes, or if you smoke;
* a history of heart attack, stroke, or blood clot;
* a history of stomach ulcers or bleeding;
* asthma;
* liver or kidney disease; or
* fluid retention.
Taking indomethacin during the last 3 months of pregnancy may harm the
unborn baby. Tell your doctor if you are pregnant or plan to become
pregnant while using indomethacin.
Indomethacin can pass into breast milk and may harm a nursing baby. You
should not breast-feed while using this medicine.
Indomethacin is not approved for use by anyone younger than 14 years
old.
How should I take indomethacin (Indocin, Indocin SR, Tivorbex)?
Follow all directions on your prescription label. Do not take this
medicine in larger amounts or for longer than recommended. Use the
lowest dose that is effective in treating your condition.
Do not crush, chew, break, or open an extended-release capsule. Swallow
it whole.
If you take indomethacin for a long period of time, your doctor may
want to check you on a regular basis to make sure this medicine is not
causing harmful effects.
Store at room temperature away from moisture and heat. Do not allow the
liquid medicine to freeze.
Indocin Patient Information including If I Miss a Dose
Rheumatoid Arthritis Symptoms and Treatment
Rheumatoid Arthritis Slideshow
RxList
Take the RA Quiz
Rheumatoid Arthritis Exercises:Joint-Friendly Fitness Routines
Joint-Friendly Exercises Slideshow
What happens if I miss a dose (Indocin, Indocin SR, Tivorbex)?
Take the missed dose as soon as you remember. Skip the missed dose if
it is almost time for your next scheduled dose. Do not take extra
medicine to make up the missed dose.
What happens if I overdose (Indocin, Indocin SR, Tivorbex)?
Seek emergency medical attention or call the Poison Help line at
1-800-222-1222. Overdose symptoms may include vomiting, severe
headache, dizziness, confusion, numbness, tingling, or seizure
(convulsions).
What should I avoid while taking indomethacin (Indocin, Indocin SR,
Tivorbex)?
Avoid drinking alcohol. It may increase your risk of stomach bleeding.
Avoid taking aspirin while you are taking indomethacin.
Ask a doctor or pharmacist before using any cold, allergy, or pain
medicine. Many medicines available over the counter contain aspirin or
other medicines similar to indomethacin. Taking certain products
together can cause you to get too much of this type of medication.
Check the label to see if a medicine contains aspirin, ibuprofen,
ketoprofen, or naproxen.
What other drugs will affect indomethacin (Indocin, Indocin SR, Tivorbex)?
Ask your doctor before using indomethacin if you take an antidepressant
such as citalopram, escitalopram, fluoxetine (Prozac),
fluvoxamine, paroxetine, sertraline (Zoloft),
trazodone, or vilazodone. Taking any of these medicines with an
NSAID may cause you to bruise or bleed easily.
Ask a doctor or pharmacist if it is safe for you to use indomethacin if
you are also using any of the following drugs:
* cyclosporine;
* lithium;
* methotrexate;
* probenecid;
* a blood thinner (warfarin, Coumadin, Jantoven);
* heart or blood pressure medication, including a diuretic or
"water pill"; or
* steroid medicine (such as prednisone).
This list is not complete. Other drugs may interact with indomethacin,
including prescription and over-the-counter medicines, vitamins, and
herbal products. Not all possible interactions are listed in this
medication guide.
Where can I get more information (Indocin, Indocin SR, Tivorbex)?
Your pharmacist can provide more information about indomethacin.
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