* Generic Name: imipramine
* Brand Name: Tofranil
* What is imipramine (Tofranil, Tofranil-PM)?
* What are the possible side effects of imipramine (Tofranil,
Tofranil-PM)?
* What is the most important information I should know about
imipramine (Tofranil, Tofranil-PM)?
* What should I discuss with my healthcare provider before taking
imipramine (Tofranil, Tofranil-PM)?
* How should I take imipramine (Tofranil, Tofranil-PM)?
* What happens if I miss a dose (Tofranil, Tofranil-PM)?
* What happens if I overdose (Tofranil, Tofranil-PM)?
* What should I avoid while taking imipramine (Tofranil,
Tofranil-PM)?
* What other drugs will affect imipramine (Tofranil,
Tofranil-PM)?
* Where can I get more information (Tofranil, Tofranil-PM)?
What is imipramine (Tofranil, Tofranil-PM)?
Imipramine is a tricyclic antidepressant. Imipramine affects
chemicals in the brain that may be unbalanced in people with
depression.
Imipramine is used to treat symptoms of depression. Imipramine is
sometimes used to treat bed-wetting in children ages 6 and older.
Imipramine may also be used for purposes not listed in this medication
guide.
What are the possible side effects of imipramine (Tofranil, Tofranil-PM)?
Get emergency medical help if you have signs of an allergic reaction:
hives; difficult breathing; swelling of your face, lips, tongue, or
throat.
Report any new or worsening symptoms to your doctor, such as: mood or
behavior changes, anxiety, panic attacks, trouble sleeping, or if
you feel impulsive, irritable, agitated, hostile, aggressive, restless,
hyperactive (mentally or physically), more depressed, or have thoughts
about suicide or hurting yourself.
Call your doctor at once if you have:
* blurred vision, tunnel vision, eye pain or swelling, or
seeing halos around lights;
* a light-headed feeling, like you might pass out;
* new or worsening chest pain, pounding heartbeats or fluttering in
your chest;
* sudden numbness or weakness, problems with vision, speech, or
balance;
* fever, sore throat;
* confusion, hallucinations, unusual thoughts or behavior;
* painful or difficult urination;
* seizure (convulsions); or
* jaundice (yellowing of the skin or eyes).
Common side effects may include:
* tingly feeling, weakness, lack of coordination;
* dry mouth, nausea, vomiting, constipation, diarrhea;
* vision changes, ringing in your ears;
* breast swelling (in men or women); or
* decreased sex drive, impotence, or difficulty having an
orgasm.
This is not a complete list of side effects and others may occur. Call
your doctor for medical advice about side effects. You may report side
effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about imipramine
(Tofranil, Tofranil-PM)?
You should not take this medicine if you recently had a heart
attack.
Do not use this medicine if you have used an MAO inhibitor in the past
14 days, such as isocarboxazid, linezolid, methylene blue
injection, phenelzine, rasagiline, selegiline, or tranylcypromine.
Some young people have thoughts about suicide when first taking an
antidepressant. Stay alert to changes in your mood or symptoms. Report
any new or worsening symptoms to your doctor.
Tofranil Patient Information including How Should I Take
Depression Overview:What is Depression?
Understanding Depression Slideshow
RxList
Take the Depression Quiz
Depression:Tips for Exercise Diet and Stress Reduction
Depression Tips Slideshow Pictures
What should I discuss with my healthcare provider before taking imipramine
(Tofranil, Tofranil-PM)?
You should not use imipramine if you are allergic to it, or if:
* you recently had a heart attack; or
* you are allergic to other antidepressants (amitriptyline,
amoxapine, clomipramine, desipramine, doxepin,
nortriptyline, protriptyline, or trimipramine).
Do not use imipramine if you have used an MAO inhibitor in the past 14
days. A dangerous drug interaction could occur. MAO inhibitors include
isocarboxazid, linezolid, methylene blue injection, phenelzine,
rasagiline, selegiline, tranylcypromine, and others.
To make sure imipramine is safe for you, tell your doctor if you have:
* heart disease, a history of heart attack, stroke, or
seizures;
* bipolar disorder (manic-depression), schizophrenia or
other mental illness;
* kidney or liver disease;
* overactive thyroid, adrenal gland tumor
(pheochromocytoma);
* diabetes (imipramine may raise or lower blood sugar);
* narrow-angle glaucoma;
* problems with urination; or
* a condition for which you are being treated with
electroconvulsive therapy (ECT).
Some young people have thoughts about suicide when first taking an
antidepressant. Stay alert to changes in your mood or symptoms. Report
any new or worsening symptoms to your doctor.
It is not known whether this medicine will harm an unborn baby. Tell
your doctor if you are pregnant or plan to become pregnant.
Imipramine can pass into breast milk and may harm a nursing baby. You
should not breast-feed while using this medicine.
Older adults may be more sensitive to the effects of this medicine.
Do not give this medicine to a child without medical advice. Imipramine
is not approved to treat depression in anyone younger than 18 years
old. Imipramine should not be used to treat bed-wetting in a child
younger than 6 years old.
How should I take imipramine (Tofranil, Tofranil-PM)?
Follow all directions on your prescription label. Your doctor may
occasionally change your dose to make sure you get the best results. Do
not use this medicine in larger or smaller amounts or for longer than
recommended.
If you need surgery, tell the surgeon ahead of time that you are
using imipramine. You may need to stop using the medicine for a short
time.
It may take up to 3 weeks before your symptoms improve. Keep using the
medication as directed and tell your doctor if your symptoms do not
improve.
Call your doctor if your symptoms do not improve, or if they get worse.
You should not stop using imipramine suddenly. Follow your doctor's
instructions about tapering your dose.
Store at room temperature away from moisture, heat, and light. Keep the
bottle tightly closed when not in use.
Tofranil Patient Information including If I Miss a Dose
Depression Overview:What is Depression?
Understanding Depression Slideshow
RxList
Take the Depression Quiz
Depression:Tips for Exercise Diet and Stress Reduction
Depression Tips Slideshow Pictures
What happens if I miss a dose (Tofranil, Tofranil-PM)?
Take the missed dose as soon as you remember. Skip the missed dose if
it is almost time for your next scheduled dose. Do not take extra
medicine to make up the missed dose.
What happens if I overdose (Tofranil, Tofranil-PM)?
Seek emergency medical attention or call the Poison Help line at
1-800-222-1222. An overdose of imipramine can be fatal.
Overdose symptoms may include extreme drowsiness, fast or irregular
heart rate, fainting, or seizure (convulsions).
What should I avoid while taking imipramine (Tofranil, Tofranil-PM)?
Do not drink alcohol. Dangerous side effects or death can occur when
alcohol is combined with imipramine. Check your food and medicine
labels to be sure these products do not contain alcohol.
Imipramine can cause side effects that may impair your thinking or
reactions. Be careful if you drive or do anything that requires you to
be awake and alert.
Avoid exposure to sunlight or tanning beds. Imipramine can make you
sunburn more easily. Wear protective clothing and use sunscreen
(SPF 30 or higher) when you are outdoors.
What other drugs will affect imipramine (Tofranil, Tofranil-PM)?
Taking this medicine with other drugs that make you sleepy can worsen
this effect. Ask your doctor before taking imipramine with a sleeping
pill, narcotic pain medicine, muscle relaxer, or medicine for
anxiety, depression, or seizures.
Many drugs can interact with imipramine. Not all possible interactions
are listed here. Tell your doctor about all your current medicines and
any you start or stop using, especially:
* any other antidepressant;
* cimetidine (Tagamet);
* clonidine;
* guanethidine;
* bladder or urinary medicines such as darifenacin, fesoterodine,
oxybutynin, tolterodine, solifenacin;
* bronchodilators such as aclidinium, ipratropium,
tiotropium, or umeclidinium;
* cold or allergy medicine;
* diet pills, stimulants, ADHD medication (such as
Ritalin or Adderall);
* medication for Parkinson's disease;
* medication to treat excess stomach acid, stomach ulcer,
motion sickness, or irritable bowel syndrome; or
* seizure medicine such as phenytoin or phenobarbital.
Many drugs can interact with imipramine. This includes prescription and
over-the-counter medicines, vitamins, and herbal products. Not all
possible interactions are listed in this medication guide. Tell your
doctor about all medicines you use, and those you start or stop using
during your treatment with imipramine. Give a list of all your
medicines to any healthcare provider who treats you.
Where can I get more information (Tofranil, Tofranil-PM)?
Your pharmacist can provide more information about imipramine.
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