* Generic Name: sorafenib
* Brand Name: Nexavar
* What is sorafenib (NexAVAR)?
* What are the possible side effects of sorafenib (NexAVAR)?
* What is the most important information I should know about
sorafenib (NexAVAR)?
* What should I discuss with my health care provider before
taking sorafenib (NexAVAR)?
* How should I take sorafenib (NexAVAR)?
* What happens if I miss a dose (NexAVAR)?
* What happens if I overdose (NexAVAR)?
* What should I avoid while taking sorafenib (NexAVAR)?
* What other drugs will affect sorafenib (NexAVAR)?
* Where can I get more information (NexAVAR)?
What is sorafenib (NexAVAR)?
Sorafenib is a cancer medication that interferes with the growth and
spread of cancer cells in the body.
Sorafenib is used to treat liver cancer, thyroid cancer, or a
type of kidney cancer called advanced renal cell carcinoma.
Sorafenib may also be used for purposes not listed in this medication
guide.
What are the possible side effects of sorafenib (NexAVAR)?
Get emergency medical help if you have signs of an allergic reaction:
hives; difficult breathing; swelling of your face, lips, tongue, or
throat.
Stop using sorafenib and call your doctor at once if you have:
* mouth sores;
* blood in your urine or stools, coughing up blood or vomit
that looks like coffee grounds;
* heavy menstrual periods, easy bruising, unusual bleeding, or any
bleeding that will not stop;
* pale skin, feeling light-headed, rapid heart rate, trouble
concentrating;
* dry cough, wheezing;
* chest pain and severe dizziness, fainting, sweating, swelling,
rapid weight gain, feeling short of breath (even with mild
exertion);
* rash, blisters, oozing, or severe pain in the palms of your
hands or the soles of your feet;
* upper stomach pain, itching, loss of appetite, dark urine,
clay-colored stools, jaundice (yellowing of the skin or eyes);
* sudden weight loss, increased appetite, trouble sleeping,
increased bowel movements, feeling hot, feeling nervous or anxious,
swelling in your neck (goiter);
* dangerously high blood pressure (severe headache, blurred
vision, buzzing in your ears, confusion, uneven heartbeats,
seizure); or
* severe skin reaction -- fever, sore throat, swelling in your
face or tongue, burning in your eyes, skin pain, followed by a red
or purple skin rash that spreads (especially in the face or upper
body) and causes blistering and peeling.
Common side effects may include:
* tired feeling;
* vomiting, diarrhea, mild stomach pain;
* mild itching or rash; or
* weight loss, thinning hair.
This is not a complete list of side effects and others may occur. Call
your doctor for medical advice about side effects. You may report side
effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about sorafenib
(NexAVAR)?
You should not use sorafenib if you have squamous cell lung cancer
and you are being treated with carboplatin (Paraplatin) and
paclitaxel (Onxol, Taxol, Abraxane).
Sorafenib can cause heart problems. Stop taking this medicine and call
your doctor at once if you have chest pain and severe dizziness,
fainting, sweating, or feeling short of breath.
Sorafenib can also cause severe bleeding. Call your doctor if you have
blood in your urine or stools, abnormal vaginal bleeding, severe
stomach pain, coughing up blood, or any bleeding that will not stop.
Nexavar Patient Information including How Should I Take
Digestive Disease Myths:Common Misconceptions
Digestive Disease Myths Slideshow Pictures
RxList
10 Facts About the Amazing Brain
Weight Gain Shockers:Surprising Reasons You're Gaining Weight
Weight Gain Shockers Slideshow
What should I discuss with my health care provider before taking sorafenib
(NexAVAR)?
You should not use sorafenib if you are allergic to it, or if you have
squamous cell lung cancer and you are being treated with carboplatin
(Paraplatin) and paclitaxel (Onxol, Taxol, Abraxane).
To make sure sorafenib is safe for you, tell your doctor if you have:
* kidney or liver problems other than cancer;
* lung cancer;
* a bleeding or blood clotting disorder such as hemophilia;
* high blood pressure (hypertension), heart disease, slow
heartbeats, congestive heart failure, chest pain;
* a personal or family history of Long QT syndrome;
* a history of stroke or heart attack; or
* any allergies.
Do not use sorafenib if you are pregnant. It could harm the unborn
baby.
Use birth control to prevent pregnancy while you are receiving
sorafenib, whether you are a man or a woman. Tell your doctor right
away if a pregnancy occurs while either parent is taking this
medication. Keep using birth control for at least 2 weeks after your
treatment ends.
It is not known whether sorafenib passes into breast milk or if it
could harm a nursing baby. You should not breast-feed while using this
medicine.
How should I take sorafenib (NexAVAR)?
Sorafenib is usually taken 2 times per day. Follow all directions on
your prescription label. Do not take this medicine in larger or smaller
amounts or for longer than recommended.
Take sorafenib on an empty stomach, at least 1 hour before or 2 hours
after eating.
Do not crush, chew, or break a sorafenib tablet. Swallow it whole with
water.
Your blood pressure will need to be checked often.
If you need surgery or dental work, tell the surgeon or dentist
ahead of time that you are using sorafenib. You may need to stop using
the medicine for a short time.
Store at room temperature away from moisture and heat.
Nexavar Patient Information including If I Miss a Dose
Digestive Disease Myths:Common Misconceptions
Digestive Disease Myths Slideshow Pictures
RxList
10 Facts About the Amazing Brain
Weight Gain Shockers:Surprising Reasons You're Gaining Weight
Weight Gain Shockers Slideshow
What happens if I miss a dose (NexAVAR)?
Take the missed dose as soon as you remember, but at least 2 hours
since your last meal. Skip the missed dose if it is almost time for
your next scheduled dose. Do not take extra medicine to make up the
missed dose.
What happens if I overdose (NexAVAR)?
Seek emergency medical attention or call the Poison Help line at
1-800-222-1222.
What should I avoid while taking sorafenib (NexAVAR)?
This medicine can pass into body fluids (urine, feces, vomit).
Caregivers should wear rubber gloves while cleaning up a patient's body
fluids, handling contaminated trash or laundry or changing diapers.
Wash hands before and after removing gloves. Wash soiled clothing and
linens separately from other laundry.
What other drugs will affect sorafenib (NexAVAR)?
Tell your doctor about all other cancer medicines you use, especially
cisplatin, cyclophosphamide, docetaxel, doxorubicin,
fluorouracil, gemcitabine, irinotecan, paclitaxel, or
tamoxifen.
Many drugs can interact with sorafenib. Not all possible interactions
are listed here. Tell your doctor about all your medications and any
you start or stop using during treatment with sorafenib, especially:
* dexamethasone;
* neomycin;
* St. John's wort;
* a blood thinner (warfarin, Coumadin);
* seizure medication--carbamazepine, fosphenytoin,
phenobarbital, phenytoin; or
* tuberculosis medicine--rifabutin, rifampin.
This list is not complete and many other drugs can interact with
sorafenib. This includes prescription and over-the-counter medicines,
vitamins, and herbal products. Give a list of all your medicines to any
healthcare provider who treats you.
Where can I get more information (NexAVAR)?
Your pharmacist can provide more information about sorafenib.
__________________________________________________________________
No comments:
Post a Comment