* Generic Name: linezolid
* Brand Name: Zyvox
* What is linezolid?
* What are the possible side effects of linezolid?
* What is the most important information I should know about
linezolid?
* What should I discuss with my healthcare provider before using
linezolid?
* How is linezolid used?
* What happens if I miss a dose?
* What happens if I overdose?
* What should I avoid while using linezolid?
* What other drugs will affect linezolid?
* Where can I get more information?
What is linezolid?
Linezolid is an antibiotic that fights bacteria in the body.
Linezolid is also an MAO (monoamine oxidase) inhibitor.
Linezolid is used to treat different types of bacterial infections,
such as pneumonia, skin infections, and infections that are
resistant to other antibiotics.
Linezolid may also be used for purposes not listed in this medication
guide.
What are the possible side effects of linezolid?
Get emergency medical help if you have signs of an allergic reaction
(hives, difficult breathing, swelling in your face or throat) or a
severe skin reaction (fever, sore throat, burning eyes, skin pain,
red or purple skin rash with blistering and peeling).
Call your doctor at once if you have:
* vision problems, changes in color vision;
* severe stomach pain, diarrhea that is watery or bloody;
* a seizure;
* sweating, feeling anxious or shaky (may be signs of low blood
sugar);
* high levels of serotonin in the body--agitation,
hallucinations, fever, sweating, shivering, fast heart rate,
muscle stiffness, twitching, loss of coordination, nausea,
vomiting, diarrhea;
* lactic acidosis--unusual muscle pain, trouble breathing,
stomach pain, vomiting, irregular heart rate, dizziness, feeling
cold, or feeling very weak or tired; or
* low blood cell counts--fever, chills, tiredness, weakness,
confusion, mouth sores, skin sores, easy bruising, unusual
bleeding, pale skin, cold hands and feet, feeling
light-headed or short of breath.
Seek medical attention right away if you have symptoms of serotonin
syndrome, such as: agitation, hallucinations, fever, sweating,
shivering, fast heart rate, muscle stiffness, twitching, loss of
coordination, nausea, vomiting, or diarrhea.
Common side effects may include:
* nausea, vomiting, diarrhea;
* mild skin rash;
* anemia (low red blood cells); or
* headache, dizziness.
This is not a complete list of side effects and others may occur. Call
your doctor for medical advice about side effects. You may report side
effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about linezolid?
Some medicines can cause unwanted or dangerous effects when used with
linezolid. Tell your doctor about all other medicines you use.
Do not use this medicine if you have used an MAO inhibitor in the past
14 days, such as isocarboxazid, linezolid, methylene blue
injection, phenelzine, rasagiline, selegiline, or tranylcypromine.
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What should I discuss with my healthcare provider before using linezolid?
You should not use linezolid if you are allergic to it.
Do not use linezolid if you have taken an MAO inhibitor in the past 14
days. A dangerous drug interaction could occur. MAO inhibitors include
isocarboxazid, methylene blue injection, phenelzine, rasagiline,
selegiline, and tranylcypromine.
Tell your doctor if you have ever had:
* high blood pressure;
* a thyroid disorder;
* a carcinoid tumor;
* bone marrow suppression or a weak immune system;
* kidney or liver disease;
* pheochromocytoma (adrenal gland tumor);
* diabetes;
* seizures; or
* if you use a catheter.
It is not known whether linezolid will harm an unborn baby. Tell your
doctor if you are pregnant.
It may not be safe to breast-feed a baby while you are using this
medicine. Ask your doctor about any risks.
Linezolid liquid may contain phenylalanine. Tell your doctor if you
have phenylketonuria (PKU).
How is linezolid used?
Follow all directions on your prescription label and read all
medication guides or instruction sheets. Use the medicine exactly as
directed.
Linezolid tablets or liquid can be taken with or without food.
Linezolid injection is given as an infusion into a vein. A healthcare
provider will give your first dose and may teach you how to properly
use the medication by yourself.
Prepare your injection only when you are ready to give it. Do not use
if the medicine has particles in it. Call your pharmacist for new
medicine.
Read and carefully follow any Instructions for Use provided with your
medicine. Do not use linezolid if you don't understand all instructions
for proper use. Ask your doctor or pharmacist if you have questions.
Gently mix the oral suspension (liquid) by turning the bottle upside
down 3 to 5 times. Do not shake. Use the dosing syringe provided, or
use a medicine dose-measuring device (not a kitchen spoon).
You will need frequent medical tests. Your vision and blood pressure
may also need to be checked often.
Use this medicine for the full prescribed length of time, even if your
symptoms quickly improve. Skipping doses can increase your risk of
infection that is resistant to medication. Linezolid will not treat a
viral infection such as the flu or a common cold.
Store all forms of linezolid at room temperature away from moisture,
heat, and light. Do not freeze. Throw away any liquid not used within
21 days.
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What happens if I miss a dose?
Use the medicine as soon as you can, but skip the missed dose if it is
almost time for your next dose. Do not use two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at
1-800-222-1222.
What should I avoid while using linezolid?
Antibiotic medicines can cause diarrhea, which may be a sign of a new
infection. If you have diarrhea that is watery or bloody, call your
doctor before using anti-diarrhea medicine.
Eating tyramine while you are using linezolid can raise your blood
pressure to dangerous levels. Avoid foods that have a high level of
tyramine, such as:
* aged cheeses or meats;
* pickled or fermented meats, smoked or air-dried meats;
* sauerkraut;
* soy sauce;
* tap beer (alcoholic and nonalcoholic);
* red wine; or
* any meat, cheese, or other protein-based food that has been
improperly stored.
You should be very familiar with the list of foods you must avoid while
you are using linezolid.
What other drugs will affect linezolid?
Some medicines can interact with linezolid and cause a serious
condition called serotonin syndrome. Be sure your doctor knows if you
also take stimulant medicine, opioid medicine, herbal products, or
medicine for depression, mental illness, Parkinson's disease,
migraine headaches, serious infections, or prevention of nausea
and vomiting. Ask your doctor before making any changes in how or when
you take your medications.
Many drugs can interact with linezolid, and some drugs should not be
used together. This includes prescription and over-the-counter
medicines, vitamins, and herbal products. Not all possible interactions
are listed in this medication guide. Tell your doctor about all your
current medicines and any medicine you start or stop using.
Where can I get more information?
Your pharmacist can provide more information about linezolid.
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