* Generic Name: glyburide and metformin
* Brand Name: Glucovance
* What is glyburide and metformin (Glucovance)?
* What are the possible side effects of glyburide and metformin
(Glucovance)?
* What is the most important information I should know about
glyburide and metformin (Glucovance)?
* What should I discuss with my healthcare provider before taking
glyburide and metformin (Glucovance)?
* How should I take glyburide and metformin (Glucovance)?
* What happens if I miss a dose (Glucovance)?
* What happens if I overdose (Glucovance)?
* What should I avoid while taking glyburide and metformin
(Glucovance)?
* What other drugs will affect glyburide and metformin
(Glucovance)?
* Where can I get more information (Glucovance)?
What is glyburide and metformin (Glucovance)?
Glyburide and metformin is a combination of two oral
diabetes medicines that help control blood sugar levels.
Glyburide and metformin is used together with diet and exercise
to improve blood sugar control in adults with type 2 diabetes. This
medicine is not for treating type 1 diabetes.
Glyburide and metformin may also be used for purposes not listed in
this medication guide.
What are the possible side effects of glyburide and metformin (Glucovance)?
Get emergency medical help if you have signs of an allergic reaction:
hives; difficult breathing; swelling of your face, lips, tongue, or
throat.
Stop using this medicine and call your doctor at once if you have:
* shortness of breath (even with mild exertion), swelling, rapid
weight gain; or
* symptoms of lactic acidosis--muscle pain or weakness,
numbness or cold feeling in your arms and legs, trouble breathing,
stomach pain, nausea with vomiting, slow or uneven heart rate,
dizziness, or feeling very weak or tired.
Common side effects may include:
* low blood sugar;
* nausea, diarrhea, upset stomach; or
* headache.
This is not a complete list of side effects and others may occur. Call
your doctor for medical advice about side effects. You may report side
effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about glyburide and
metformin (Glucovance)?
You should not use this medicine if you have severe kidney disease, if
you also take bosentan (Tracleer), or if you have metabolic
acidosis or diabetic ketoacidosis (call your doctor for
treatment).
If you need to have any type of x-ray or CT scan using a dye that is
injected into your veins, you will need to temporarily stop taking
glyburide and metformin.
Some people taking metformin develop a serious condition called
lactic acidosis. Stop taking this medicine and get emergency
medical help if you have even mild symptoms such as: muscle pain or
weakness, numb or cold feeling in your arms and legs, trouble
breathing, stomach pain, nausea with vomiting, slow or uneven heart
rate, dizziness, or feeling very weak or tired.
Glucovance Patient Information including How Should I Take
Type 2 Diabetes Diagnosis, Treatment, Medication
Type 2 Diabetes: Learn the Warning Signs
Diabetes: Best and Worst Meals for Diabetes-Savvy Dining
Diabetes Friendly Dining
RxList
Type 2 Diabetes Quiz
What should I discuss with my healthcare provider before taking glyburide and
metformin (Glucovance)?
You should not use this medicine if you are allergic to glyburide or
metformin, or:
* severe kidney disease;
* metabolic acidosis or diabetic ketoacidosis (call your doctor
for treatment); or
* if you are also using bosentan (to treat pulmonary arterial
hypertension).
If you need to have any type of x-ray or CT scan using a dye that is
injected into your veins, you will need to temporarily stop taking
glyburide and metformin.
Some people taking metformin develop a serious condition called lactic
acidosis. This may be more likely if you have liver or kidney disease,
surgery, congestive heart failure, a heart attack or
stroke, a severe infection, if you are 65 or older, if you are
dehydrated, or if you drink a lot of alcohol. Talk with your doctor
about your risk.
To make sure glyburide and metformin is safe for you, tell your doctor
if you have ever had:
* kidney disease;
* an enzyme deficiency called glucose-6-phosphate dehydrogenase
deficiency (G6PD);
* liver disease; or
* heart disease, heart attack, or stroke.
It is not known whether glyburide and metformin will harm an unborn
baby. Similar diabetes medications have caused severe hypoglycemia
in newborn babies whose mothers had used the medication near the time
of delivery. Tell your doctor if you are pregnant or plan to become
pregnant while using this medicine.
It is not known whether this medicine passes into breast milk or if it
could harm a nursing baby. You should not breast-feed while taking
glyburide and metformin.
How should I take glyburide and metformin (Glucovance)?
Follow all directions on your prescription label. Your doctor may
occasionally change your dose. Do not take this medicine in larger or
smaller amounts or for longer than recommended.
Take glyburide and metformin with meals.
Your blood sugar will need to be checked often, and you may need other
blood tests at your doctor's office.
Call your doctor if you are sick with vomiting, diarrhea, or a fever.
These conditions can lead to severe dehydration, which could be
dangerous while you are taking glyburide and metformin.
Drink plenty of liquids while you are taking glyburide and metformin.
Low blood sugar (hypoglycemia) can happen to everyone who has diabetes.
Symptoms include headache, hunger, sweating, irritability, dizziness,
nausea, fast heart rate, and feeling anxious or shaky. To quickly treat
low blood sugar, always keep a fast-acting source of sugar with you
such as fruit juice, hard candy, crackers, raisins, or non-diet soda.
Your doctor can prescribe a glucagon emergency injection kit to use
in case you have severe hypoglycemia and cannot eat or drink. Be sure
your family and close friends know how to give you this injection in an
emergency.
Also watch for signs of high blood sugar (hyperglycemia) such as
increased thirst or urination, blurred vision, headache, and
tiredness.
Blood sugar levels can be affected by stress, illness, surgery,
exercise, alcohol use, or skipping meals. Ask your doctor before
changing your dose or medication schedule.
Your doctor may have you take extra vitamin B12 while you are
taking glyburide and metformin. Take only the amount of vitamin B12
that your doctor has prescribed.
Glyburide and metformin is only part of a treatment program that may
also include diet, exercise, weight control, and special medical care.
Follow your doctor's instructions very closely.
Store at room temperature away from moisture, heat, and light.
Glucovance Patient Information including If I Miss a Dose
Type 2 Diabetes Diagnosis, Treatment, Medication
Type 2 Diabetes: Learn the Warning Signs
Diabetes: Best and Worst Meals for Diabetes-Savvy Dining
Diabetes Friendly Dining
RxList
Type 2 Diabetes Quiz
What happens if I miss a dose (Glucovance)?
Take the missed dose as soon as you remember (be sure to take the
medicine with food). Skip the missed dose if it is almost time for your
next scheduled dose. Do not take extra medicine to make up the missed
dose.
What happens if I overdose (Glucovance)?
Seek emergency medical attention or call the Poison Help line at
1-800-222-1222. An overdose can cause life-threatening hypoglycemia.
Symptoms of severe hypoglycemia include extreme weakness,
confusion, tremors, sweating, fast heart rate, trouble
speaking, nausea, vomiting, rapid breathing, fainting, and
seizure (convulsions).
Overdose may also cause lactic acidosis symptoms such as muscle pain,
numbness, trouble breathing, vomiting, slow heart rate, and extreme
weakness.
What should I avoid while taking glyburide and metformin (Glucovance)?
Avoid drinking alcohol. It lowers blood sugar and may increase your
risk of lactic acidosis.
If you also take colesevelam, avoid taking it within 4 hours after you
take glyburide and metformin.
What other drugs will affect glyburide and metformin (Glucovance)?
There are many other medicines that can increase or decrease the
effects of glyburide and metformin on lowering your blood sugar. This
includes prescription and over-the-counter medicines, vitamins, and
herbal products. Tell each of your health care providers about all
medicines you use now and any medicine you start or stop using.
Where can I get more information (Glucovance)?
Your pharmacist can provide more information about glyburide and
metformin.
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