* Generic Name: ondansetron hydrochloride tablets and solution
* Brand Name: Zofran
* What is ondansetron (Zofran, Zofran ODT, Zuplenz)?
* What are the possible side effects of ondansetron (Zofran,
Zofran ODT, Zuplenz)?
* What is the most important information I should know about
ondansetron (Zofran, Zofran ODT, Zuplenz)?
* What should I discuss with my health care provider before
taking ondansetron (Zofran, Zofran ODT, Zuplenz)?
* How should I take ondansetron (Zofran, Zofran ODT, Zuplenz)?
* What happens if I miss a dose (Zofran, Zofran ODT, Zuplenz)?
* What happens if I overdose (Zofran, Zofran ODT, Zuplenz)?
* What should I avoid while taking ondansetron (Zofran, Zofran
ODT, Zuplenz)?
* What other drugs will affect ondansetron (Zofran, Zofran ODT,
Zuplenz)?
* Where can I get more information (Zofran, Zofran ODT, Zuplenz)?
What is ondansetron (Zofran, Zofran ODT, Zuplenz)?
Ondansetron blocks the actions of chemicals in the body that can
trigger nausea and vomiting.
Ondansetron is used to prevent nausea and vomiting that may be
caused by surgery, cancer chemotherapy, or radiation treatment.
Ondansetron may be used for purposes not listed in this medication
guide.
What are the possible side effects of ondansetron (Zofran, Zofran ODT,
Zuplenz)?
Get emergency medical help if you have signs of an allergic reaction:
rash, hives; fever, chills, difficult breathing; swelling of your face,
lips, tongue, or throat.
Call your doctor at once if you have:
* severe constipation, stomach pain, or bloating;
* headache with chest pain and severe dizziness, fainting, fast
or pounding heartbeats;
* fast or pounding heartbeats;
* jaundice (yellowing of the skin or eyes);
* blurred vision or temporary vision loss (lasting from only a
few minutes to several hours);
* high levels of serotonin in the body--agitation,
hallucinations, fever, fast heart rate, overactive reflexes,
nausea, vomiting, diarrhea, loss of coordination, fainting.
Common side effects may include:
* diarrhea or constipation;
* headache;
* drowsiness; or
* tired feeling.
This is not a complete list of side effects and others may occur. Call
your doctor for medical advice about side effects. You may report side
effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about ondansetron
(Zofran, Zofran ODT, Zuplenz)?
You should not use ondansetron if you are also using apomorphine
(Apokyn).
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What should I discuss with my health care provider before taking ondansetron
(Zofran, Zofran ODT, Zuplenz)?
You should not use ondansetron if:
* you are also using apomorphine (Apokyn); or
* you are allergic to ondansetron or similar medicines (dolasetron,
granisetron, palonosetron).
To make sure ondansetron is safe for you, tell your doctor if you have:
* liver disease;
* an electrolyte imbalance (such as low levels of potassium
or magnesium in your blood);
* congestive heart failure, slow heartbeats;
* a personal or family history of long QT syndrome; or
* a blockage in your digestive tract (stomach or intestines).
Ondansetron is not expected to harm an unborn baby. Tell your doctor if
you are pregnant.
It is not known whether ondansetron passes into breast milk or if it
could harm a nursing baby. Tell your doctor if you are breast-feeding a
baby.
Ondansetron is not approved for use by anyone younger than 4 years old.
Ondansetron orally disintegrating tablets may contain
phenylalanine. Tell your doctor if you have phenylketonuria
(PKU).
How should I take ondansetron (Zofran, Zofran ODT, Zuplenz)?
Follow all directions on your prescription label. Do not take this
medicine in larger or smaller amounts or for longer than recommended.
Ondansetron can be taken with or without food.
The first dose of ondansetron is usually taken before the start of your
surgery, chemotherapy, or radiation treatment. Follow your doctor's
dosing instructions very carefully.
Take the ondansetron regular tablet with a full glass of water.
To take the orally disintegrating tablet (Zofran ODT):
* Keep the tablet in its blister pack until you are ready to take it.
Open the package and peel back the foil. Do not push a tablet
through the foil or you may damage the tablet.
* Use dry hands to remove the tablet and place it in your mouth.
* Do not swallow the tablet whole. Allow it to dissolve in your mouth
without chewing.
* Swallow several times as the tablet dissolves.
To use ondansetron oral soluble film (strip) (Zuplenz):
* Keep the strip in the foil pouch until you are ready to use the
medicine.
* Using dry hands, remove the strip and place it on your tongue. It
will begin to dissolve right away.
* Do not swallow the strip whole. Allow it to dissolve in your mouth
without chewing.
* Swallow several times after the strip dissolves. If desired, you
may drink liquid to help swallow the dissolved strip.
* Wash your hands after using Zuplenz.
Measure liquid medicine with the dosing syringe provided, or with a
special dose-measuring spoon or medicine cup. If you do not have a
dose-measuring device, ask your pharmacist for one.
Store at room temperature away from moisture, heat, and light. Store
liquid medicine in an upright position.
Zofran Patient Information including If I Miss a Dose
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What happens if I miss a dose (Zofran, Zofran ODT, Zuplenz)?
Take the missed dose as soon as you remember. Skip the missed dose if
it is almost time for your next scheduled dose. Do not take extra
medicine to make up the missed dose.
What happens if I overdose (Zofran, Zofran ODT, Zuplenz)?
Seek emergency medical attention or call the Poison Help line at
1-800-222-1222.
Overdose symptoms may include sudden loss of vision, severe
constipation, feeling light-headed, or fainting.
What should I avoid while taking ondansetron (Zofran, Zofran ODT, Zuplenz)?
Ondansetron may impair your thinking or reactions. Be careful if you
drive or do anything that requires you to be alert.
What other drugs will affect ondansetron (Zofran, Zofran ODT, Zuplenz)?
Ondansetron can cause a serious heart problem, especially if you use
certain medicines at the same time, including antibiotics,
antidepressants, heart rhythm medicine, antipsychotic
medicines, and medicines to treat cancer, malaria, HIV or
AIDS. Tell your doctor about all medicines you use, and those you
start or stop using during your treatment with ondansetron.
Taking ondansetron while you are using certain other medicines can
cause high levels of serotonin to build up in your body, a condition
called "serotonin syndrome," which can be fatal. Tell your doctor if
you also use:
* medicine to treat depression;
* medicine to treat a psychiatric disorder;
* a narcotic (opioid) medication; or
* medicine to prevent nausea and vomiting.
This list is not complete and many other drugs can interact with
ondansetron. This includes prescription and over-the-counter medicines,
vitamins, and herbal products. Give a list of all your medicines to any
healthcare provider who treats you.
Where can I get more information (Zofran, Zofran ODT, Zuplenz)?
Your pharmacist can provide more information about ondansetron.
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